International Journal of Hematology and Oncology 2023, Vol 33, Num 4 Page(s): 74-78
The Comparison Effect of Oral and Intramuscular Injection vitamin K on PT and APTT in Neonates

Mohsen JAFARZADEH1, Ashraf MOHAMMADZADEH2, Ahmad S. FARHAT3, Mohammad R. KERAMATİ4, Mohammad KHAJEDALUEİ5

1Mashhad University of Medical Science, Neonatal Research Center, Pediatric Department, IRAN
2Mashhad University of Medical Science, Neonatal Research Center, NICU, IRAN
3Mashhad University of Medical Science, Neonatal Research Center, NICU, IRAN
4Mashhad University of Medical Science, Neonatal Research Center, Department of Hematology, IRAN
5Mashhad University of Medical Science, Neonatal Research Center, Community Medical Department, IRAN

Keywords: Vitamin K deficency, Newborn, PT, APTT
The aim of this study was to determine the effect of oral versus intramuscular vitamin K on PT (Prothrombin time) and APTT (Activated partial thromboplastin time) in neonates.

Ninthy five healthy term live born neonates with birth weight more than 2500 grams who delivered in Mashhad Emmamreza hospital since 6 feb 2006 were elected. They were divided in two groups. The injection group( n=45) that recived 1 mg vitamin K (Phytonadion) intramuscularly and oral group ( n=50 ) 2 mg vitamin K Per oral in first 6 hours of age. PT and APTT was measured 12 hours after vitamin K administration.

PT and APTT was measured at 24.78 ± 9.95 hours after vitamin K injection and 22.16 ± 7.4 hours in oral groups (P=0.14 ). Mean PT in injection group was 16.77 ± 4 second and in oral group was 16.39 ± 2.98 second (P=0.38). Mean APTT in injection and oral group were 37.73 ± 22.25 second and 34.95 ± 7.73 second respectivly (P=0.69). As classic form of hemorraghic disease of the newborn is prevented with vitamin K.

This study showed that there were not significant differences in PT and APTT between two groups. Therefore both oral and intramuscular vitamin K can prevent classic hemorraghic disease of the newborn , but for showing prevention effect of oral vitamin K in late onset vitamin K further study is needed for targeting of newborns.