International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 022-031
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The Postoperative Radiotherapy Results of Patients with Primitive Neuroectodermal Tumors in Childhood
Hüseyin BORA1, Ö. Petek ERPOLAT1, Aynur OĞUZ1, Ceyda KARADENİZ1, Eray KARAHACIOĞLU1, Müge AKMANSU1
1Gazi Üniversitesi Tıp Fakültesi Radyasyon Onkolojisi Anabilim Dalı, ANKARA
2Gazi Üniversitesi Tıp Fakültesi Pediatri ABD, ANKARA
Keywords: Primitive neuroectodermal tumors, Medulloblastoma, Radiotherapy, Overall survival, Prognostic factors
The primitive neuroectodermal tumors are the second common malignancies among the childhood brain tumors. Their prognosis are quite variable and the multidisciplinary treatment approach is required. The purpose of our study is to evaluate the factors that can affect overall survival. After the surgery, seventeen patients have received the radiotherapy (median 34.2 Gy to craniospinal region and median 54 Gy to posterior fossa at a 1.5-1.8 Gy daily fractionation dose) and the chemotherapy. The average preoperative tumor volume was 41.5 cm3. Eight patients were in a standard risk group and the rest was in a high risk group. The mean follow-up time was 27.8 months and the overall survival was three years. It has been found that the overall survival was affected by the unfavorable prognostic factors such as larger (>30 cm3) preoperative tumor volume, supratentorial location, being in high risk group and more than fifty days radiotherapy treatment. The preoperative large tumor volume and prolonged radiotherapy duration were determined as unfavorable prognostic factors in our study, that differ from the literature data. Due to the limited number of the patients in this study, these results should be confirmed with additional studies with larger patient groups.
Hüseyin BORA1, Ö. Petek ERPOLAT1, Aynur OĞUZ1, Ceyda KARADENİZ1, Eray KARAHACIOĞLU1, Müge AKMANSU1
1Gazi Üniversitesi Tıp Fakültesi Radyasyon Onkolojisi Anabilim Dalı, ANKARA
2Gazi Üniversitesi Tıp Fakültesi Pediatri ABD, ANKARA
Keywords: Primitive neuroectodermal tumors, Medulloblastoma, Radiotherapy, Overall survival, Prognostic factors
The primitive neuroectodermal tumors are the second common malignancies among the childhood brain tumors. Their prognosis are quite variable and the multidisciplinary treatment approach is required. The purpose of our study is to evaluate the factors that can affect overall survival. After the surgery, seventeen patients have received the radiotherapy (median 34.2 Gy to craniospinal region and median 54 Gy to posterior fossa at a 1.5-1.8 Gy daily fractionation dose) and the chemotherapy. The average preoperative tumor volume was 41.5 cm3. Eight patients were in a standard risk group and the rest was in a high risk group. The mean follow-up time was 27.8 months and the overall survival was three years. It has been found that the overall survival was affected by the unfavorable prognostic factors such as larger (>30 cm3) preoperative tumor volume, supratentorial location, being in high risk group and more than fifty days radiotherapy treatment. The preoperative large tumor volume and prolonged radiotherapy duration were determined as unfavorable prognostic factors in our study, that differ from the literature data. Due to the limited number of the patients in this study, these results should be confirmed with additional studies with larger patient groups.
| Back | Table of Contents | Turkish Abstract | PDF | Mail to Author | |