International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 016-021
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Mitomycin C in Recurrent or Extensive Ocular Surface Neoplasia
Masoomeh EGHTEDARI1, M. Hossein ROOZITALAB1, Asadollah KATBAB1, Hossein ASHRAF1
Shiraz University of Medical Sciences, Poostchi Eye Research Center, IRAN
Keywords: Conjunctiva, Mitomycin C, Neoplasia, Ocular malignancy, Squamus cell carcinoma
Role of mitomycin C (MMC) is searched in recurrent cases with squamus cell carcinoma (SCC), conjunctival-corneal intraepithelial neoplasia (CCIN) or in advanced cases of ocular surface neoplasm in whom, surgical excision was impossible due to extensive involvement of ocular surface. Seventeen cases of SCC, CCIN or PAM(primary acquired melanosis) with atypia were selected. They received three cycles of MMC (0.04%) eye drop four times a day for one week. Participants were followed for 4-36 months. There were 7 females and 10 males.7 patients (41.1%) developed one time recurrence after first course of treatment but during follow up, only 3 of them (17.6%) needed surgical management while 4 others responded to another course of treatment. Six out of 17 patients (35.2%) had another systemic disease and received either chemotherapy or radiation before.We conclude that even though the trend for use of chemotherapy as a sole drug or in adjunct with surgery in the treatment of ocular surface neoplasia is rising, surgical resection still remains the first line procedure in the management of limited forms of CCIN or aggressive and invasive SCC while they are concise. Only in recurrent cases or extensive involvement of ocular surface, prescription of MMC may be reasonable.
Masoomeh EGHTEDARI1, M. Hossein ROOZITALAB1, Asadollah KATBAB1, Hossein ASHRAF1
Shiraz University of Medical Sciences, Poostchi Eye Research Center, IRAN
Keywords: Conjunctiva, Mitomycin C, Neoplasia, Ocular malignancy, Squamus cell carcinoma
Role of mitomycin C (MMC) is searched in recurrent cases with squamus cell carcinoma (SCC), conjunctival-corneal intraepithelial neoplasia (CCIN) or in advanced cases of ocular surface neoplasm in whom, surgical excision was impossible due to extensive involvement of ocular surface. Seventeen cases of SCC, CCIN or PAM(primary acquired melanosis) with atypia were selected. They received three cycles of MMC (0.04%) eye drop four times a day for one week. Participants were followed for 4-36 months. There were 7 females and 10 males.7 patients (41.1%) developed one time recurrence after first course of treatment but during follow up, only 3 of them (17.6%) needed surgical management while 4 others responded to another course of treatment. Six out of 17 patients (35.2%) had another systemic disease and received either chemotherapy or radiation before.We conclude that even though the trend for use of chemotherapy as a sole drug or in adjunct with surgery in the treatment of ocular surface neoplasia is rising, surgical resection still remains the first line procedure in the management of limited forms of CCIN or aggressive and invasive SCC while they are concise. Only in recurrent cases or extensive involvement of ocular surface, prescription of MMC may be reasonable.
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