International Journal of Hematology and Oncology 2019, Vol 29, Num 1 Page(s): 103-107
Familial Aggregation in Hematologic Cancers: Report of Three Cases

O. Meltem AKAY1, Göknur YORULMAZ2, Zafer GÜLBAŞ1

1Osmangazi Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Hematoloji Bilim Dalı, ESKİŞEHİR
2Osmangazi Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, ESKİŞEHİR

Keywords: Hematologic Cancers, Familial aggregation
The occurence of hematological malignancies in families has been reported for over 50 years. The occurence of familial hematological malignancies could be the result of chance, germline mutations in tumor suppressor genes or protooncogenes, or the inheritance of predisposing alleles or mutations that interact with environmental factors or aging effects to result in accumulated genetic injury sufficient to cause the cancer. We here report 3 siblings who have been diagnosed with familial hematologic cancer between 1995 and 2006 in our department are presented.