International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 094-097
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Thrombotic Thrombocytopenic Purpura Associated With Graves’ Disease
Abdullah ALTINTAŞ1, Timuçin ÇİL1, Orhan AYYILDIZ1, M. Ali KAPLAN2, Ekrem MÜFTÜOĞLU1
1Dicle University, Department of Internal Medicine, DİYARBAKIR
2Dicle University, Department of Hematology-Oncology, DİYARBAKIR
Keywords: Thrombotic thrombocytopenic purpura, Graves’ disease, Thrombocytopenia
Thrombotic thrombocytopenic purpura (TTP) is characterized by microangiopathic hemolytic anemia and thrombocytopenia, usually accompanied by fever, renal failure and neurological deficits. TTP usually occurs in previously healthy people, but in a significant number of cases, the syndrome is associated with autoimmune disorders. We report a case of a 53 year old male patient suffering from TTP associated with Graves’ disease (GD). After the diagnosis of TTP and Graves’ disease plasmapheresis and antithyroid therapy were initiated. After the 15th seans of plasmapheresis, complaints were dissolved and hematologic parameters were recovered.This case draws the reader’s attention to a rare condition that TTP associated with GD. Although immune thrombocytopenic purpura (ITP) and pernisious anemia must be initially considered in the event that thrombocytopenia accompanies to GD, TTP is likely in the presence of microangiopathy. The presence of microangiopathic haemolytic anemia and thrombocytopenia is sufficient for the diagnosis of TTP, thus prompt diagnosis and appropriate therapy is crucial for TTP.
Abdullah ALTINTAŞ1, Timuçin ÇİL1, Orhan AYYILDIZ1, M. Ali KAPLAN2, Ekrem MÜFTÜOĞLU1
1Dicle University, Department of Internal Medicine, DİYARBAKIR
2Dicle University, Department of Hematology-Oncology, DİYARBAKIR
Keywords: Thrombotic thrombocytopenic purpura, Graves’ disease, Thrombocytopenia
Thrombotic thrombocytopenic purpura (TTP) is characterized by microangiopathic hemolytic anemia and thrombocytopenia, usually accompanied by fever, renal failure and neurological deficits. TTP usually occurs in previously healthy people, but in a significant number of cases, the syndrome is associated with autoimmune disorders. We report a case of a 53 year old male patient suffering from TTP associated with Graves’ disease (GD). After the diagnosis of TTP and Graves’ disease plasmapheresis and antithyroid therapy were initiated. After the 15th seans of plasmapheresis, complaints were dissolved and hematologic parameters were recovered.This case draws the reader’s attention to a rare condition that TTP associated with GD. Although immune thrombocytopenic purpura (ITP) and pernisious anemia must be initially considered in the event that thrombocytopenia accompanies to GD, TTP is likely in the presence of microangiopathy. The presence of microangiopathic haemolytic anemia and thrombocytopenia is sufficient for the diagnosis of TTP, thus prompt diagnosis and appropriate therapy is crucial for TTP.
| Back | Table of Contents | Turkish Abstract | PDF | Mail to Author | |