International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 065-069
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Hereditary Thrombophilic Risk Factors in Patients with Deep Venous Thrombosis
Abdullah ALTINTAŞ1, Timuçin ÇİL1, M. Ali KAPLAN2, Murat YURT3, Sabri BATUN3
1Dicle Üniversitesi, İç Hastalıkları, Hematoloji-Onkoloji Bilim Dalı, DİYARBAKIR
2Dicle Üniversitesi, İç Hastalıkları Ana Bilim Dalı, DİYARBAKIR
3Dicle Üniversitesi, Biyokimya Ana Bilim Dalı-Hematoloji Laboratuarı, DİYARBAKIR
Keywords: Deep vein thrombosis, Factor V Leiden, Prothrombin G20210A
The prevalence of hereditary risk factors for deep venous thrombosis (DVT) varies greatly in different parts of the world. Factor V Leiden (FVL) and prothrombin G 20210A (PT G20210A) are the most common genetic defects leading to venous thrombosis. The aim of this study was to investigate the frequency of FVL and PT G20210A mutations in adult patient with DVT in our region. Between September 2001 and August 2006, 52 patients with documented venous thrombosis were investigated in our center for the presence of FVL and PT G20210A mutations. Fourteen of 52 patients with thrombosis (%26.9) were detected to have a FVL mutation. The PT G20210A mutation was detected in 6 (%11) of the 52 patients. Our findings reveal that FVL and PT G20210A mutations are significantly higher in patients with DVT than in the healty population in the southeast of Turkey.
Abdullah ALTINTAŞ1, Timuçin ÇİL1, M. Ali KAPLAN2, Murat YURT3, Sabri BATUN3
1Dicle Üniversitesi, İç Hastalıkları, Hematoloji-Onkoloji Bilim Dalı, DİYARBAKIR
2Dicle Üniversitesi, İç Hastalıkları Ana Bilim Dalı, DİYARBAKIR
3Dicle Üniversitesi, Biyokimya Ana Bilim Dalı-Hematoloji Laboratuarı, DİYARBAKIR
Keywords: Deep vein thrombosis, Factor V Leiden, Prothrombin G20210A
The prevalence of hereditary risk factors for deep venous thrombosis (DVT) varies greatly in different parts of the world. Factor V Leiden (FVL) and prothrombin G 20210A (PT G20210A) are the most common genetic defects leading to venous thrombosis. The aim of this study was to investigate the frequency of FVL and PT G20210A mutations in adult patient with DVT in our region. Between September 2001 and August 2006, 52 patients with documented venous thrombosis were investigated in our center for the presence of FVL and PT G20210A mutations. Fourteen of 52 patients with thrombosis (%26.9) were detected to have a FVL mutation. The PT G20210A mutation was detected in 6 (%11) of the 52 patients. Our findings reveal that FVL and PT G20210A mutations are significantly higher in patients with DVT than in the healty population in the southeast of Turkey.
| Back | Table of Contents | Turkish Abstract | PDF | Mail to Author | |