International Journal of Hematology and Oncology 2021, Vol 31, Num 4 Page(s): 165-171
PATIENTS WIH HODGKIN’S DISEASE : CLINICAL AND PATHOLOGICAL EVALUATION

Abdullah ALTINTAŞ1, Timuçin ÇİL1, M. Ali KAPLAN2, A.Engin ATAY2, Abdurrahman IŞIKDOĞAN1, Hüseyin BÜYÜKBAYRAM3, Orhan AYYILDIZ1, Ekrem MÜFTÜOĞLU1

1Dicle Üniversitesi Tıp Fakültesi İç Hastalıkları-Hematoloji-Onkoloji Bilim Dalı, DİYARBAKIR
2Dicle Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, DİYARBAKIR
3Dicle Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı, DİYARBAKIR

Keywords: Hodgkins’ disease, Lymphoma, Lymphoproliferative disease
Hodgkins’ disease accounts 25% of all lymphoid malignancies and 1% of all cancers. In this study, 150 patients with Hodgkins’ disease were reviewed retrospectively and compared according to age, gender, histopathologic subtype and stage of disease. 102 (68%) of patients were male and 48 (32%) were female with a median age of 41 (16-73) years. The frequencies of histopathological subtypes, mixed cellularity, nodular sclerosis, lymphocyte-rich and lymphocytedepletion, were 63 (42%), 37 (24.6%), 25 (16.6%) and 21 (14%), respectively. Histological subtype was not determined in 4 (2.7%) patients. Distribution of patients according to stages were; 18 (12%) patients were in stage I, 35 (23.3%) patients were in stage II, 52 (34.7%) patients were in stage III and 43 (28.7%) patients were in stage IV. Sufficient staging procedure was not performed in two patients. SPSS 11.0 program was used for statistical analyzes. Patients were divided into two groups; older and younger than 40 years age and no statistical significancy was detected between groups. Also there was no significant relation between histopathological subtype and age. In conclusion; Hodgkin disease predominantly seen in males (M/F: 2.1). Mixed celularity HD was the most frequent subtype and 63.7% of our patients were in advanced stage (stage III ve IV).