International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 145-148
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RETINOIC ACID SYNDROME AFTER THE FIRST DOSE OF ALL-TRANS RETINOIC ACID
Abdullah ALTINTAŞ1, Semir PAŞA1, Cüneyt AĞGİL1, Belma TURAL1, Orhan AYYILDIZ1
Dicle Üniversitesi Tıp Fakültesi Hematoloji - Onkoloji Bilim Dalı, DİYARBAKIR
Keywords: Retinoic acid syndrome, Acute promyelocytic leukemia, All-trans retinoic acid
All-trans retinoic acid (ATRA) was firstly used as a differentiating agent in 1987 in Shanghai for the treatment of acute promyelocytic leukemia (APL). Retinoic Acid Syndrome (RAS) became an important complication of therapy after the administration of ATRA. The frequency of syndrome is 27% and the precise cause is not entirely known. The mortality rate of patients with APL due to this complication is 1%. Symptoms of RAS resembles to sepsis, pneumonia, iatrogenic volume overload and blood transfusion reactions frequently seen in the course of leukemia and may cause confusion in the diagnosis of RAS. Dexamethasone must be administered urgently in the suspicion of RAS since it has a fatal outcome. Herein, we reported an APL patient with white blood cell count of lower than 1000/ml at presentation and complicated with retinoic acid syndrome subsequent to the first dose of all-trans retinoic acid.
Abdullah ALTINTAŞ1, Semir PAŞA1, Cüneyt AĞGİL1, Belma TURAL1, Orhan AYYILDIZ1
Dicle Üniversitesi Tıp Fakültesi Hematoloji - Onkoloji Bilim Dalı, DİYARBAKIR
Keywords: Retinoic acid syndrome, Acute promyelocytic leukemia, All-trans retinoic acid
All-trans retinoic acid (ATRA) was firstly used as a differentiating agent in 1987 in Shanghai for the treatment of acute promyelocytic leukemia (APL). Retinoic Acid Syndrome (RAS) became an important complication of therapy after the administration of ATRA. The frequency of syndrome is 27% and the precise cause is not entirely known. The mortality rate of patients with APL due to this complication is 1%. Symptoms of RAS resembles to sepsis, pneumonia, iatrogenic volume overload and blood transfusion reactions frequently seen in the course of leukemia and may cause confusion in the diagnosis of RAS. Dexamethasone must be administered urgently in the suspicion of RAS since it has a fatal outcome. Herein, we reported an APL patient with white blood cell count of lower than 1000/ml at presentation and complicated with retinoic acid syndrome subsequent to the first dose of all-trans retinoic acid.
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