International Journal of Hematology and Oncology 2019, Vol 29, Num 3 Page(s): 082-086
RADIATION-INDUCED OSTEOSARCOMA IN JUVENILE ANGIOFIBROMA: A CASE REPORT

Saadettin KILIÇKAP1, Sercan AKSOY1, Murat DİNÇER1, E. Arzu SAĞLAM2, Şuayib YALÇIN1

1Hacettepe Üniversitesi Onkoloji Enstitüsü Medikal Onkoloji Ünitesi, ANKARA
2Hacettepe Üniversitesi Tıp Fakültesi Patoloji Bölümü, ANKARA

Keywords: Juvenil angiofibroma, Radiotherapy, Secondary tumor, Osteosarcoma
Juvenil nasopharyngeal angiofibroma (JNA) is a highly vascular tumour, arising from the fibrovascular stroma on the posterolateral nasal wall. JNA can be treated surgically and/or with radiotherapy. Despite therapeutic intervention, these tumors mostly present with recurrences. Osteosarcoma is a malignant neoplasm usually involving long bones in young adults. Ionizing radiation is a risk factor for osteosarcoma, in which case it usually localizes within the radiation field. Radiation-induced osteosarcoma generally occurs after a latent period of 5 to 20 years. Its skull involvement is very rare.


Herein we report a patient with nasopharyngeal angiofibroma treated with radiotherapy, and later developed radiotherapy- induced osteosarcoma.