International Journal of Hematology and Oncology 2019, Vol 29, Num 3 Page(s): 047-053
ADJUVANT CHEMORADIOTHERAPY FOR CANCER OF THE RECTUM: POSTOPERATIVE OR PREOPERATIVE?

Bilgehan KARADAYI1, Seyit B. ZİNCİRCİOĞLU1, Ahmet DİRİER1

Dicle Üniversitesi Tıp Fakültesi Radyasyon Onkolojisi Anabilim Dalı, DİYARBAKIR

Keywords: Rectal neoplasm, Neoadjuvant Therapy, Antineoplastic Combined Chemotherapy Protocols
Cancer of the rectum is a frequent malign disease of both sexes and its primary treatment is surgery. Postoperative chemotherapy is the generally preferred adjuvant treatment modality but its results are not still satisfactory. Recent studies have reported that total mesorectal excision technique with preoperative chemoradiotherapy is superior to postoperative adjuvant treatment in terms of local disease control. The question of timing of the adjuvant treatments like radiotherapy, chemotherapy and chemoradiotherapy will be discussed in light of the randomized clinical trials with sufficient patient number. In conclusion, current recommendation is preoperative concomitant chemotherapy plus radiotherapy.