International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 144-148
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RESULTS OF TREATMENT REGIME OF FLAG-IDA-CYCLOSPORINE IN ACUTE LEUKEMIA PATIENTS REFRACTORY TO FLAG SALVAGE REGIME
Mehmet SÖNMEZ1, Mustafa YILMAZ1, Murat ERKUT2, Elif AKDOĞAN1, Ahmet DURMUŞ1, Serdar B. OMAY1, Ercüment OVALI1
1Karadeniz Teknik Üniversitesi Tıp Fakültesi Hematoloji Bilim Dalı
2Karadeniz Teknik Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, TRABZON
Keywords: Relapsed/refractory AML, ALL, FLAG-Ida-Cyclosporine
Although the salvage regimens can induce complete remission in refractory acute leukemia patients, it is generally short and rarely cure is achieved. The plan for refractory patients with respect to salvage regimens is problematic. The emergence of multidrug resistance cause the inefficiency of chemotherapy protocols. Cyclosporine is one of the agents to overcome the drug resistance. In this study, we planned to test the efficiency of hybrid regime FLAG-Ida- Cyclosporine in the refractory cases to FLAG. 9 patients who were primary refractory or relapsed to FLAG salvage regime comprising 5 AML, 3 ALL and 1 T-lymphoblastic lymphoma were enrolled. In 3 out of 5 AML patients, complete remission was observed, however none of ALL and T-lymphoblastic lymphoma patients entered remission. These results suggested that FLAG-Ida-Cyclosporine therapy can be an alternative in the AML patients primary refractory or early relapsed to FLAG salvage regimen, in contrast to the inefficiency in ALL cases.
Mehmet SÖNMEZ1, Mustafa YILMAZ1, Murat ERKUT2, Elif AKDOĞAN1, Ahmet DURMUŞ1, Serdar B. OMAY1, Ercüment OVALI1
1Karadeniz Teknik Üniversitesi Tıp Fakültesi Hematoloji Bilim Dalı
2Karadeniz Teknik Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, TRABZON
Keywords: Relapsed/refractory AML, ALL, FLAG-Ida-Cyclosporine
Although the salvage regimens can induce complete remission in refractory acute leukemia patients, it is generally short and rarely cure is achieved. The plan for refractory patients with respect to salvage regimens is problematic. The emergence of multidrug resistance cause the inefficiency of chemotherapy protocols. Cyclosporine is one of the agents to overcome the drug resistance. In this study, we planned to test the efficiency of hybrid regime FLAG-Ida- Cyclosporine in the refractory cases to FLAG. 9 patients who were primary refractory or relapsed to FLAG salvage regime comprising 5 AML, 3 ALL and 1 T-lymphoblastic lymphoma were enrolled. In 3 out of 5 AML patients, complete remission was observed, however none of ALL and T-lymphoblastic lymphoma patients entered remission. These results suggested that FLAG-Ida-Cyclosporine therapy can be an alternative in the AML patients primary refractory or early relapsed to FLAG salvage regimen, in contrast to the inefficiency in ALL cases.
| Back | Table of Contents | Turkish Abstract | PDF | Mail to Author | |