International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 057-062
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POTENTIAL RISK FACTOR OF INTERLEUKIN-10 GENE POLYMORPHISM IN ACUTE MYELOGENOUS LEUKEMIA
Bilkay BAŞTÜRK1, Elif EVKE2, Sema KARAKUŞ3, Ahmet TUNALI4
1Başkent Üniversitesi Tıp Fakültesi, İç Hastalıkları Ana Bilim Dalı, İmmünoloji Bölümü, ANKARA
2Uludağ Üniversitesi Merkez Laboratuarı, BURSA
3Başkent Üniversitesi Tıp Fakültesi Hematoloji Bilim Dalı, ANKARA
4Uludağ Üniversitesi Tıp Fakültesi Hematoloji Bilim Dalı, BURSA
Keywords: AML, Cytokine, Genotype, Polymorphism
Acute leukemias are a heterogeneous group of disorders of the pluripotent stem cell. In current study we investigated the association of the cytokine gene polymorphisms with the development of acute myelogenous leukemia (AML). The study included 23 patients with the diagnosis of AML and 60 healthy controls. All genotyping (TNF- α, TGF- β, IL-10, IL-6, IFN- γ) studies were performed using sequence specific primers PCR (PCR-SSP).
The cytokine genotyping results of the patients were compared to those of the healthy controls. It was found that IL- 10 -1082 GCC/ATA polymorphism were significantly higher in the patient with AML group than the healthy control group. On the other hand, IL-10 -1082 ACC/ATA polymorphisms were significantly lower in the AML group than the healthy control group. It was found that IFN- γ+874 T/A polymorphism was correlated with white blood cell count. These results suggest that IL-10 GCC/ATA polymorphism is a potential risk factor for AML, whereas IL-10 ACC/ATA polymorphism is a possible protective factor.
Bilkay BAŞTÜRK1, Elif EVKE2, Sema KARAKUŞ3, Ahmet TUNALI4
1Başkent Üniversitesi Tıp Fakültesi, İç Hastalıkları Ana Bilim Dalı, İmmünoloji Bölümü, ANKARA
2Uludağ Üniversitesi Merkez Laboratuarı, BURSA
3Başkent Üniversitesi Tıp Fakültesi Hematoloji Bilim Dalı, ANKARA
4Uludağ Üniversitesi Tıp Fakültesi Hematoloji Bilim Dalı, BURSA
Keywords: AML, Cytokine, Genotype, Polymorphism
Acute leukemias are a heterogeneous group of disorders of the pluripotent stem cell. In current study we investigated the association of the cytokine gene polymorphisms with the development of acute myelogenous leukemia (AML). The study included 23 patients with the diagnosis of AML and 60 healthy controls. All genotyping (TNF- α, TGF- β, IL-10, IL-6, IFN- γ) studies were performed using sequence specific primers PCR (PCR-SSP).
The cytokine genotyping results of the patients were compared to those of the healthy controls. It was found that IL- 10 -1082 GCC/ATA polymorphism were significantly higher in the patient with AML group than the healthy control group. On the other hand, IL-10 -1082 ACC/ATA polymorphisms were significantly lower in the AML group than the healthy control group. It was found that IFN- γ+874 T/A polymorphism was correlated with white blood cell count. These results suggest that IL-10 GCC/ATA polymorphism is a potential risk factor for AML, whereas IL-10 ACC/ATA polymorphism is a possible protective factor.
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