International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 151-156
CLINICAL EVALUATION OF BONE MARROW METASTASIS
EMEL GÜRKAN1, BİROL GÜVENÇ1, FİKRİ BAŞLAMİŞLİ1, BURHAN HAZAR1
Çukurova Üniversitesi Tıp Fakültesi İç Hastalıkları Hematoloji ve Onkoloji Bilim Dalı, ADANA
Keywords: myelophthisic anemia, bone marrow, metastases
The hematological picture caused by the infiltration of the bone marrow is defined as myelophythisic anemia. The most frequent cause of the bone marrow infiltration is the metastatic carcinomas. In this study we have presented eight patients who were admitted to our outpatient department with bone marrow infiltration as the first sign of their disease. Retrospectively hospital files of the patients referred to our hematology department between November 1994 and December 1998 were evaluated. At referral in one of the cases with metastatic adenocarcinoma (prostate) there were anemia, thrombocytopenia and leukocytosis; and in the other one anemia and thrombocytopenia. In two cases with gastric carcinoma anemia and thrombocytopenia and in the patients with metastatic adenocarcinoma of unknown origin two had anemia, thrombocytopenia and leukocytosis and the other one had pancytopenia; in the patient with adrenal tumor pancytopenia was seen at presentation. When the bone marrow involvement of these patients examined, some of them has shown hypocellularity, some hypercellular marrow origin. In conclusion, we have discussed bone marrow metastasis in solid tumors and in this respect literature is reviewed.
EMEL GÜRKAN1, BİROL GÜVENÇ1, FİKRİ BAŞLAMİŞLİ1, BURHAN HAZAR1
Çukurova Üniversitesi Tıp Fakültesi İç Hastalıkları Hematoloji ve Onkoloji Bilim Dalı, ADANA
Keywords: myelophthisic anemia, bone marrow, metastases
The hematological picture caused by the infiltration of the bone marrow is defined as myelophythisic anemia. The most frequent cause of the bone marrow infiltration is the metastatic carcinomas. In this study we have presented eight patients who were admitted to our outpatient department with bone marrow infiltration as the first sign of their disease. Retrospectively hospital files of the patients referred to our hematology department between November 1994 and December 1998 were evaluated. At referral in one of the cases with metastatic adenocarcinoma (prostate) there were anemia, thrombocytopenia and leukocytosis; and in the other one anemia and thrombocytopenia. In two cases with gastric carcinoma anemia and thrombocytopenia and in the patients with metastatic adenocarcinoma of unknown origin two had anemia, thrombocytopenia and leukocytosis and the other one had pancytopenia; in the patient with adrenal tumor pancytopenia was seen at presentation. When the bone marrow involvement of these patients examined, some of them has shown hypocellularity, some hypercellular marrow origin. In conclusion, we have discussed bone marrow metastasis in solid tumors and in this respect literature is reviewed.