International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 138-143
EVALUATION OF SEROCONVERTION RESPONSE TO THE HEPATITIS A VACCINATION IN CHILDREN WITH CANCER
DURGÜL ÖZDEMİR1, PAMİR GÜLEZ1, ERTAN KAYSERİLİ1, ALPAY ÖZBEK1, CANAN VERGİN1
Dr. Behçet Uz Çocuk Hastalıkları Eğitim ve Araştırma Hastanesi, İZMİR
Keywords: hepatitis a, cancer, seroconvertion
In children with cancer, hepatitis A infection causes both delaying the chemotherapy program in its usual clinical course and high mortality rate in its rarely seen fulminant form. The aim of this study to evaluate the intensity of chemotherapy protocols and doses of the vaccine to the efficiacy of the hepatitis A vaccination which used in 0, 1, 6 months as protecting patients with cancer from hepatitis A infection. Hepatitis A vaccine administered in 25 children with hematologic malignancy, aged 3 to 15 years, seronegative for hepatitis A infection and had normal liver function tests. Hepatitis A vaccine randomly administered one dose in 12 patients and double doses in 13 patients without considering the intensity of the chemoteherapy program. The control group was constituted 6 healthy children who were administered one dose vaccine. Total anti HAV titers were determined on 1, 2, 7 months and the childrens who their antibody titers were equal or higher than 20 mIU/ml accepted as seropositive. Anti HAV titers were determined on 1, 2, 7 months respectively as 23.7, 36.6, 48.4 mIU/ml in children receiving one dose vaccine and 34.0, 54.5, 160.3 mIU/ml receiving double doses vaccine. Seroconvertion rates were determined as 33.3%, 41.6%, 50% in the group receiving one dose vaccine and 53.8%, 84.6%, 100% receiving double doses vaccine. They were also found 16.6%, 16.6%, 16.6% in children receiving both one dose vaccine and intensive chemotherapy and 50%, 66.6%, 66.6% receiving nonintensive chemotherapy; and 42.8%, 100%, 100% in children receiving both double doses vaccine and intensive chemotherapy, 66.6%, 83.3%, 100% receiving nonintensive chemotherapy. These values were found 66.6%, 83.3%, 100% in the control group. These results showed double doses hepatitis A vaccination program was effective to prevent hepatitis A infection in children with cancer.
DURGÜL ÖZDEMİR1, PAMİR GÜLEZ1, ERTAN KAYSERİLİ1, ALPAY ÖZBEK1, CANAN VERGİN1
Dr. Behçet Uz Çocuk Hastalıkları Eğitim ve Araştırma Hastanesi, İZMİR
Keywords: hepatitis a, cancer, seroconvertion
In children with cancer, hepatitis A infection causes both delaying the chemotherapy program in its usual clinical course and high mortality rate in its rarely seen fulminant form. The aim of this study to evaluate the intensity of chemotherapy protocols and doses of the vaccine to the efficiacy of the hepatitis A vaccination which used in 0, 1, 6 months as protecting patients with cancer from hepatitis A infection. Hepatitis A vaccine administered in 25 children with hematologic malignancy, aged 3 to 15 years, seronegative for hepatitis A infection and had normal liver function tests. Hepatitis A vaccine randomly administered one dose in 12 patients and double doses in 13 patients without considering the intensity of the chemoteherapy program. The control group was constituted 6 healthy children who were administered one dose vaccine. Total anti HAV titers were determined on 1, 2, 7 months and the childrens who their antibody titers were equal or higher than 20 mIU/ml accepted as seropositive. Anti HAV titers were determined on 1, 2, 7 months respectively as 23.7, 36.6, 48.4 mIU/ml in children receiving one dose vaccine and 34.0, 54.5, 160.3 mIU/ml receiving double doses vaccine. Seroconvertion rates were determined as 33.3%, 41.6%, 50% in the group receiving one dose vaccine and 53.8%, 84.6%, 100% receiving double doses vaccine. They were also found 16.6%, 16.6%, 16.6% in children receiving both one dose vaccine and intensive chemotherapy and 50%, 66.6%, 66.6% receiving nonintensive chemotherapy; and 42.8%, 100%, 100% in children receiving both double doses vaccine and intensive chemotherapy, 66.6%, 83.3%, 100% receiving nonintensive chemotherapy. These values were found 66.6%, 83.3%, 100% in the control group. These results showed double doses hepatitis A vaccination program was effective to prevent hepatitis A infection in children with cancer.