International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 119-125
SURVIVAL AND PROGNOSTIC FACTORS IN PATIENTS WITH HODGKIN'S DISEASE
YEŞİM ERALP1, SEVİL BAVBEK1, MERT BAŞARAN1, ÖNER DOĞAN1, HAKAN ÇAMLICA1, ESRA KAYTAN1, EMİN DARENDELİLER1, HALUK ONAT1
Department of Medical Oncology, İstanbul University Institute of Oncology
Keywords: hodgkin's disease , prognostic factors, survival
Purpose: The aim of this study is to determine the overall and progression free survival in patients with Hodgkin Disease (HD) and evaluate the prognostic factors associated with an adverse outcome. Methods: Patients with histologically confirmed HD; treated and followed in our clinic between 1991-98 were evaluated retrospectively for response to treatment, survival and prognostic factors. Patients were classified into 3 prognostic groups: early stage (I-IIIa) without clinical prognostic factors (group 1), early stage with clinical prognostic factors (group 2), advanced stage patients (IIIb-IV; group 3) and treated accordingly. Results: Out of 125 patients, 27(21.6%) patients with advanced disease, 56(44.8%) with early stage and additional clinical prognostic factors were treated with primary chemotherapy. Seventy-one patients (85.6%) were given standard anthracycline-based combination. After a median follow-up period of 40 months; 70 (55.6%) patients remain with no evidence of disease and 16 (19.3%) have died. Overall survival (OS) at 7 years in the 1st group was 97.0%; in the 2nd group OS at 5 and 7 years were 81.0% and 60.0%, respectively and that of the 3rd group at 3 years was 80.8%.OS at 5 and 7 years for the whole group were 86.5 and 76.9%, respectively. Progression free survival (PSF) for the latter group at 5 years was 74.1%.Median survival was not reached in either group. Univariate analysis revealed that ESR (40mm/hr) (p:0.0004), age >= 50 years (p:0.0001) and the presence of clinical prognostic factors (p:0.0089) were associated with a poor prognosis.Age >=50 years and ESR >=40mm/hr were shown to be independent prognostic factors by multivariate analysis. Conclusion: ESR(40mm/hr) and age >=50 years are major prognostic factors with an adverse effect on the outcome of patients with HD.
YEŞİM ERALP1, SEVİL BAVBEK1, MERT BAŞARAN1, ÖNER DOĞAN1, HAKAN ÇAMLICA1, ESRA KAYTAN1, EMİN DARENDELİLER1, HALUK ONAT1
Department of Medical Oncology, İstanbul University Institute of Oncology
Keywords: hodgkin's disease , prognostic factors, survival
Purpose: The aim of this study is to determine the overall and progression free survival in patients with Hodgkin Disease (HD) and evaluate the prognostic factors associated with an adverse outcome. Methods: Patients with histologically confirmed HD; treated and followed in our clinic between 1991-98 were evaluated retrospectively for response to treatment, survival and prognostic factors. Patients were classified into 3 prognostic groups: early stage (I-IIIa) without clinical prognostic factors (group 1), early stage with clinical prognostic factors (group 2), advanced stage patients (IIIb-IV; group 3) and treated accordingly. Results: Out of 125 patients, 27(21.6%) patients with advanced disease, 56(44.8%) with early stage and additional clinical prognostic factors were treated with primary chemotherapy. Seventy-one patients (85.6%) were given standard anthracycline-based combination. After a median follow-up period of 40 months; 70 (55.6%) patients remain with no evidence of disease and 16 (19.3%) have died. Overall survival (OS) at 7 years in the 1st group was 97.0%; in the 2nd group OS at 5 and 7 years were 81.0% and 60.0%, respectively and that of the 3rd group at 3 years was 80.8%.OS at 5 and 7 years for the whole group were 86.5 and 76.9%, respectively. Progression free survival (PSF) for the latter group at 5 years was 74.1%.Median survival was not reached in either group. Univariate analysis revealed that ESR (40mm/hr) (p:0.0004), age >= 50 years (p:0.0001) and the presence of clinical prognostic factors (p:0.0089) were associated with a poor prognosis.Age >=50 years and ESR >=40mm/hr were shown to be independent prognostic factors by multivariate analysis. Conclusion: ESR(40mm/hr) and age >=50 years are major prognostic factors with an adverse effect on the outcome of patients with HD.