International Journal of Hematology and Oncology 2022, Vol 32, Num 2 Page(s): 080-086
THE AFFECTING FACTORS OF THE NUMBER OF BONE METASTASES IN BREAST CANCER

HÜSEYİN BORA1, SİBEL TUĞRAL1, İBRAHİM EGEHAN1, MÜGE AKMANSU1

Gazi Üniversitesi Tıp Fakültesi Radyasyon Onkolojisi Anabilim Dalı, ANKARA

Keywords: breast cancer, bone metastasis
Bone metastases are one of the most common problems in breast cancer patients. Although, patients who have just only bone metastases have longer survival than patients with visceral metastases, the number and the place of the metastases are important factors in the quality of life. In this study, affecting factors the numbers of bone metastases were analyzed in breast cancer. Between 1996 and 1999, 238 breast cancer patients who applied to outpatient department of Radiation Oncology Clinic of Gazi University Medical Faculty were entered into study. The study population consisted of 65 patients who suffered from bone metastases at the time of diagnosis. Metastatic foci of these patients determined by either bone scintigraphy or radiological methods were counted. The effects of factors such as age, menstrual status, tumor size, lymph node status, chemotherapy receiving applied and tamoxifen administration on number of metastases were studied. The average age was 46.34 (26-73) and the average metastasis rate was 5.38 per person (1-19). Age, menstrual status, tumor size and lymph node status had no significant affects on the number of metastases (p>0.05). However, the probability of development of more than three metastases was high in those cases to which adjuvant tamoxifen was administered at the time of diagnosis, whereas, it was low in those cases that taxol was added to their chemotherapy (p<0.05). Additionally, the period with no evidence of disease with regard to bone metastasis was higher in those patients who were regimen tamoxifen than that patient who were not. This period was 4.5 years on the average in patients receiving tamoxifen whereas; it was 2.9 years in patient not receiving it (p<0.05). According to this study, although, multivariate analyses indicate a linear relation between tamoxifen administration and metastasis rate, in order to get more concise results the number of cases and evaluated factors must be increased.