International Journal of Hematology and Oncology 2022, Vol 32, Num 4 Page(s): 223-226
TUBERCULOSIS AND HYPOPLASTIC PANCYTOPENIA

NESLİHAN BASÇİL1, SERDAR TUNCER1, TANJU TÜTÜNCÜ1, İBRAHİM C. HAZNEDAROĞLU1

Hacettepe University, Faculty of Medicine, Department of Internal Medicine, ANKARA

Keywords: tuberculosis, hypoplastic pancytopenia
Although tuberculosis may represent with variable hematologic manifestations, pancytopenia with hypoplastic bone marrow is uncommon. Polymerase chain reaction (PCR) is the method of choice for the diagnosis of tuberculosis in cases where the suspicion is high. A 30 year old man was admitted to our hospital with low-grade fever, malaise, arthralgia, weight loss, productive cough and gingival bleeding. Anemia (Hb level 6.9 g/dl), leukopenia (wbc 0.7x109/lt) and thrombocytopenia (platelet count 50x9) were detected. Clinical suspicion of milliary tuberculosis with the presenting features of fever, cough and chronic fibrotic changes on chest radiograms have prompted us to demonstrate the Mycobacterium tuberculosis bacilli. Using the PCR technique Mycobacterium tuberculosis bacilli DNA were detected in the bone marrow. Antituberculosis therapy was begun but the patient died of superimposed nosocomial infection with Xanthomonas maltophilia before the improvement of the hematologic parameters.