International Journal of Hematology and Oncology 2021, Vol 31, Num 4 Page(s): 133-140
CLASSIFICATION OF NODAL NON-HODGKIN LYMPHOMA WITH RESPECT TO OR B CELL ORIGIN AND ASSOCIATION WITH BCL-2 ONCOPROTEIN

NESRİN GÜRSAN1, MUZAFFER KELEŞ1, CEMAL GÜNDOĞDU1, MUHARREM BİTİREN1, ZEKAİ ERMAN1

Atatürk Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı,ERZURUM

Keywords: non-hodgkin's lymphoma, immunohistochemistry, bcl-2 oncoprotein
Ninety-eight patients with the diagnosis of nodal Non-Hodgkin Lymphoma admitted to Pathology Department, Medical School, Atatürk University between 1988-1995 were retrospectively evaluated. The cell origin (T or B type) was determined immunohistochemicially and the cases were reclassified according to the criteria of National Cancer institute. In addition, immunohistochemical staining was done with bcl-2 oncoprotein and its distribution in the cases was determined. While staining was more intense in B-cell type lymphoma as the maturation increased, staining showed decreased intensity in T-cell type lymphoma which are identical to literature.