International Journal of Hematology and Oncology 2021, Vol 31, Num 1 Page(s): 106-114
A NEW MODALITY IN CANCER THERAPY: ANTISENSE INHIBITION OF GENE EXPRESSION

UĞUR MUŞABAK1, ALİ ŞENGÜL1, ALİ İNAL1, YUSUF AKCAN1

Mevki Asker Hastanesi İç Hastalıkları Kliniği, İZMİR

Keywords: cancer, gene therapy, antisense oligodeoxynucleotide
In the 21 th century, the aim of cancer therapy consists of improvement and usage of new drugs that kill the neoplastic cells selectively and pose least toxicity on the normal cells. The synthesis of oligodeoxynucleotides as an anticancer agent is a new modality in this regard. Antisense oligonucleotides are short DNA fragments composed of 15 or more nucleotides that are complementary to mRNA chains. These agents inhibit mRNA which encodes the synthesis of various cellulary important proteins related to the proliferation and growth of neoplastic cells or viruses.