International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 100-105
TUMOR ANGIOGENESIS AND TREATMENT
FEYYAZ ÖZDEMİR1, FAZIL AYDIN1, KUBİLAY UKİNÇ1
Karadeniz Teknik Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, TRABZON
Keywords: tumor angiogenesis, antiangiogenic therapy
Tumor cells tend to remain silent for a long period till day gain a malignant potential and start uncontrolled proliferation accompanied with angiogenesis. The aim of all antiangiogenetic treatment protocols is keeping the endotelial cells in their normal form and at the same time inhibition of cell proliferation and migration. As the process of inhibition of cell proliferation in the capillary bed is much more slower than tumor lysis, this type of treatment with angiogenesis inhibitors must be long and continuous. Side effect such bone marrow suppression, gastrointestinal system dysfunction and alopecia are less prominent with angiogenesis inhibitors compared with those of conventional cytotoxic treatment. The combination of angiogenesis inhibitors with conventional cytotoxic agents is more effective than the effect of each group alone.
FEYYAZ ÖZDEMİR1, FAZIL AYDIN1, KUBİLAY UKİNÇ1
Karadeniz Teknik Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, TRABZON
Keywords: tumor angiogenesis, antiangiogenic therapy
Tumor cells tend to remain silent for a long period till day gain a malignant potential and start uncontrolled proliferation accompanied with angiogenesis. The aim of all antiangiogenetic treatment protocols is keeping the endotelial cells in their normal form and at the same time inhibition of cell proliferation and migration. As the process of inhibition of cell proliferation in the capillary bed is much more slower than tumor lysis, this type of treatment with angiogenesis inhibitors must be long and continuous. Side effect such bone marrow suppression, gastrointestinal system dysfunction and alopecia are less prominent with angiogenesis inhibitors compared with those of conventional cytotoxic treatment. The combination of angiogenesis inhibitors with conventional cytotoxic agents is more effective than the effect of each group alone.