International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 082-087
THE FREQUENCY OF P53 MUTATION IN PATIENTS WITH HEPATOCELLULAR CARCINOMA AND ITS CORRELATION WITH CLINICOPATHOLOGICAL FINDINGS
RÜÇHAN USLU1, CEM CENGİZ1, ULUS ALİ ŞANLİ1, V. CANFEZA SEZGİN1, GÜRAY SAYDAM1, BÜLENT KARABULUT1, FUNDA YILMAZ1, GÜL YÜCE1, TANKUT İLTER1, SERDAR BEDİİ OMAY1, ERDEM GÖKER1
Ege Üniversitesi Tıp Fakültesi Tıbbi Onkoloji Bilim Dalı, İZMİR
Keywords: mp53, hepatocellular carcinoma
Hepatocellular carcinoma is the most prevalent tumor of the liver presenting as a malign epithelial cancer. There are studies which have shown that there is a causal relationship between mutant p53 which is a tumor supressor gene and a pathogenesis of HCC. In this study the expression of mutant p53 and its correlation's with the ethnology, the number of nodules and histopathologic al type have been investigated in the tissue samples of 52 cases with the diagnosis of HCC. As the result, mutant p53 has been detected in the 50% of the cases. However, there was no correlation with gender, age, the number of nodules, the diameter of the tumor, HBV seropositivity, HCV seropositivity, alcohol consumption and histopathology.
RÜÇHAN USLU1, CEM CENGİZ1, ULUS ALİ ŞANLİ1, V. CANFEZA SEZGİN1, GÜRAY SAYDAM1, BÜLENT KARABULUT1, FUNDA YILMAZ1, GÜL YÜCE1, TANKUT İLTER1, SERDAR BEDİİ OMAY1, ERDEM GÖKER1
Ege Üniversitesi Tıp Fakültesi Tıbbi Onkoloji Bilim Dalı, İZMİR
Keywords: mp53, hepatocellular carcinoma
Hepatocellular carcinoma is the most prevalent tumor of the liver presenting as a malign epithelial cancer. There are studies which have shown that there is a causal relationship between mutant p53 which is a tumor supressor gene and a pathogenesis of HCC. In this study the expression of mutant p53 and its correlation's with the ethnology, the number of nodules and histopathologic al type have been investigated in the tissue samples of 52 cases with the diagnosis of HCC. As the result, mutant p53 has been detected in the 50% of the cases. However, there was no correlation with gender, age, the number of nodules, the diameter of the tumor, HBV seropositivity, HCV seropositivity, alcohol consumption and histopathology.