International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 070-076
THE EFFECT OF GRANULOCYTE MACROPHAGE-COLONY STIMULATING FACTOR ON WOUND HEALING IN THE TOTAL BODY IRRADIATED ANIMAL MODEL: A HISTOPATHOLOGICAL EVALUATION
DİCLEHAN KILIÇ1, İBRAHİM EGEHAN1, LEYLA MEMİŞ1
Gazi Üniversitesi Tip Fakültesi Radyasyon Onkolojisi Anabilim Dalı, ANKARA
Keywords: radiotherapy, wound healing, gm-csf
Preoperative radiotherapy is frequently used in the curative management of cancer. Because of the adverse effects of radiotherapy on skin, surgery may be delayed and this diminishes the curative effect on the tumor. In this controlled, randomized study; it was aimed to evaluate the effect of GM-CSF administered topically on the preoperatively irradiated wound healing in the meaning of histopathological evaluation. Half of the rats were irradiated as 8 Gy total body irradiation and 2 days after irradiation, they were randomized into four groups. Group 1: control, group 2: GM-CSF administered, group 3: irradiated control group, group 4: irradiated and GM-CSF administered. 11 days after irradiation, tissue samples were taken. In animals given irradiation, GM-CSF application was found to improve the delayed wound healing by histopathological evaluation. GM-CSF was found useful in the irradiated skin wound. Further investigations are required to determine the mechanism involved.
DİCLEHAN KILIÇ1, İBRAHİM EGEHAN1, LEYLA MEMİŞ1
Gazi Üniversitesi Tip Fakültesi Radyasyon Onkolojisi Anabilim Dalı, ANKARA
Keywords: radiotherapy, wound healing, gm-csf
Preoperative radiotherapy is frequently used in the curative management of cancer. Because of the adverse effects of radiotherapy on skin, surgery may be delayed and this diminishes the curative effect on the tumor. In this controlled, randomized study; it was aimed to evaluate the effect of GM-CSF administered topically on the preoperatively irradiated wound healing in the meaning of histopathological evaluation. Half of the rats were irradiated as 8 Gy total body irradiation and 2 days after irradiation, they were randomized into four groups. Group 1: control, group 2: GM-CSF administered, group 3: irradiated control group, group 4: irradiated and GM-CSF administered. 11 days after irradiation, tissue samples were taken. In animals given irradiation, GM-CSF application was found to improve the delayed wound healing by histopathological evaluation. GM-CSF was found useful in the irradiated skin wound. Further investigations are required to determine the mechanism involved.