International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 134-140
EXPRESSION OF CD44 AND CD54 ADHESION MOLECULES IN PEDIATRIC HODGKIN'S DISEASE
BİLGE BİLGİÇ1, FERHAN AKİCİ1, REJİN KEBUDİ1, İNCİ AYAN1, ÖMER GÖRGÜN1, ÖNER DOĞAN1
İstanbul Üniversitesi İstanbul Tıp Fakültesi, Patoloji Anabilim Dalı
Keywords: hodgkin's disease, adhesion molecule
Adhesion molecules are complex protein and carbohydrate molecules found on the surface of a variety of cells. They are involved in cell-cell and cell-matrix interactions. Adhesion molecules participate in leukocyte migration, lymphocyte evolution. endothel damage and inflammation. Their functions in tumor biology and metastasis are still investigated. The purpose of the present study was to investigate immunohistochemically the expression of the adhesion molecules CD44 and CD54 in pediatric Hodgkin's disease and its eorrelation with the clinicopathological parameters. Twenty two patients were included and both adhesion molecules were expressed in all cases, in tumoral and nontumoral cells. Control group consisted of 5 tonsil and 5 lymph node material without neoplastic infiltration. No significant relationship between the CD44 and CD54 expression and the clinicopathological findings were found. In conclusion. the expression of CD44 and CD54 does not seem to be of significance in the diagnosis and prognosis of pediatric Hodgkin's disease.
BİLGE BİLGİÇ1, FERHAN AKİCİ1, REJİN KEBUDİ1, İNCİ AYAN1, ÖMER GÖRGÜN1, ÖNER DOĞAN1
İstanbul Üniversitesi İstanbul Tıp Fakültesi, Patoloji Anabilim Dalı
Keywords: hodgkin's disease, adhesion molecule
Adhesion molecules are complex protein and carbohydrate molecules found on the surface of a variety of cells. They are involved in cell-cell and cell-matrix interactions. Adhesion molecules participate in leukocyte migration, lymphocyte evolution. endothel damage and inflammation. Their functions in tumor biology and metastasis are still investigated. The purpose of the present study was to investigate immunohistochemically the expression of the adhesion molecules CD44 and CD54 in pediatric Hodgkin's disease and its eorrelation with the clinicopathological parameters. Twenty two patients were included and both adhesion molecules were expressed in all cases, in tumoral and nontumoral cells. Control group consisted of 5 tonsil and 5 lymph node material without neoplastic infiltration. No significant relationship between the CD44 and CD54 expression and the clinicopathological findings were found. In conclusion. the expression of CD44 and CD54 does not seem to be of significance in the diagnosis and prognosis of pediatric Hodgkin's disease.