International Journal of Hematology and Oncology 2019, Vol 29, Num 2 Page(s): 115-121
THE PROGNOSTIC FACTORS FOR LOCAL DISEASE FREE SURVIVAL AND DISTANT DISEASE FREE SURVIVAL IN STAGE I-III BREAST CANCER PATIENTS TREATED WITH ADJUVANT CYCLOPHOSPHAMIDE-ADRIAMYCIN-5-FLUOROURACIL (CAF) CHEMOTHERAPY

BAŞAK OYAN1, NİLÜFER GÜLER1, GÜLTEN TEKUZMAN1, AYŞE KARS1, ALEV TÜRKER1, M. KADRİ ALTUNDAĞ1, YAVUZ ÖZIŞIK1, EŞMEN BALTALI1, İSMAİL ÇELİK1, ERHAN HAMALOĞLU1, ZAFER ÖNER1

Hacettepe Üniversitesi Tıp Fakültesi, Onkoloji Enstitüsü, Medikal Onkoloji Bölümü

Keywords: breast cancer, caf, prognostic factors, adjuvant chemotherapy
In this study. 248 breast cancer patients treated with adjuvant cyclophosphamide-adriamycin-5-fluorouracil (CAF) chcmotherapy between 1987 and 2000 were evaluated for local disease free survival (LDFS), distant disease free survival (DDFS) and the prognostic factors affecting LDFS and DDFS. The mean age of the patients were 44.6 years (range: 21-75). The majority of the patients were premenopausal (71%).Estrogen receptor positivity was %48 in 151 patients. Progesterone receptor positivity was %47 in 130 patients. According to TNM classificalion 3.6%, 59.3% and 34.7% of the patients were at stage I, II and III, respectively. During the median follow-up time of 24.1 months (range: 4.8 - 156.2). 19 patients and 57 patients developed local recurrence and distant recurrence, respectively. In univariate analyses, statisticaliy significant predictors for local disease free survival age, nodal status, number of focus of the tumor and receptor status; and for distant disease free survival age, nodal status, maximum size of metastatic lymph nodes. number of focus of the tumor and stage. in multivariate analyses, number of metastatic lymph nodes was the most significant independent prognostic factor for local disease free survival and distant disease free survival. While tumor multicentricity was another independent factor for local disease free survival, age and tumor multicentricity were the other independent prognostic factors for distant disease free survival. We conclude that the number of metastatic axillary lymph nodes, especially when more than 3, is the most significant prognostic factor in patients treated with CAF.