International Journal of Hematology and Oncology
2023, Vol 33, Num 4 Page(s): 107-113
IRF-1 AS IMMUNE MODULATOR AND TUMOR SUPRESSOR
NİLÜFER G. İMİR1, KAYAHAN FİŞKİN1, OSMAN N. ÖZEŞ1
Akdeniz Üniversitesi, Fen-Edebiyat Fakültesi, Biyoloji Bölümü, Antalya
Keywords: immune modulation, tumor supressor gene, irf-1
IRF-1 (Interferon Regulatory Factor-1) gene was described initially as a positive transcription factor involved in the regulation of the Type I IFN genes and IFN-inducible genes. More recently, it has been suggested by several authors that IRF-1 acts as a tumor suppressor gene. IRF-1 transcription factor belongs to the IRF family, which includes IRF-2, IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3 and ICSBP. The human IRF-1 gene is located on long arm of chromosome 5 (5q31.1). The cDNA and promotor of IRF-1 gene have been cloned and functionally characterized. To function as a transcription factor, IRF-1 requires its post-translational modifications. In several studies, it has been shown that IRF-1 is phosphorylated by dsRNA-dependent kinase PKR (p68 kinase) and Casein kinase II. And These phosphorylations affect positively biological functions of IRF-1. In recent years, it has been shown experimentally that IRF-1 plays a role in apoptosis, in phenotypic reversion, in cell growth and in cell cycle control. in addition, chromosomal deletion of IRF-1 gene is frequently detected in patients with leukemia and preleukemic syndromes. Consequently, in this paper we will review the structure and functions of IRF-1 as a immun regulator and a tumor suppressor.
NİLÜFER G. İMİR1, KAYAHAN FİŞKİN1, OSMAN N. ÖZEŞ1
Akdeniz Üniversitesi, Fen-Edebiyat Fakültesi, Biyoloji Bölümü, Antalya
Keywords: immune modulation, tumor supressor gene, irf-1
IRF-1 (Interferon Regulatory Factor-1) gene was described initially as a positive transcription factor involved in the regulation of the Type I IFN genes and IFN-inducible genes. More recently, it has been suggested by several authors that IRF-1 acts as a tumor suppressor gene. IRF-1 transcription factor belongs to the IRF family, which includes IRF-2, IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3 and ICSBP. The human IRF-1 gene is located on long arm of chromosome 5 (5q31.1). The cDNA and promotor of IRF-1 gene have been cloned and functionally characterized. To function as a transcription factor, IRF-1 requires its post-translational modifications. In several studies, it has been shown that IRF-1 is phosphorylated by dsRNA-dependent kinase PKR (p68 kinase) and Casein kinase II. And These phosphorylations affect positively biological functions of IRF-1. In recent years, it has been shown experimentally that IRF-1 plays a role in apoptosis, in phenotypic reversion, in cell growth and in cell cycle control. in addition, chromosomal deletion of IRF-1 gene is frequently detected in patients with leukemia and preleukemic syndromes. Consequently, in this paper we will review the structure and functions of IRF-1 as a immun regulator and a tumor suppressor.